Affiliation:
1. İNÖNÜ ÜNİVERSİTESİ, TURGUT ÖZAL TIP MERKEZİ
2. HİTİT ÜNİVERSİTESİ
Abstract
In this study, the effects of resveratrol (RES) on leukocyte percentages, total oxidant (TOS) -antioxidan status (TAS) and DNA damage (8-OHDG) were investigated in rats induced by methotrexate (MTX). The rats used in the study were randomly divided into 4 groups each consisting of 10 rats.Control group , MTX group (20 mg / kg ip, once a week, for two weeks) ,RES group (40 mg / kg / day orally, for two weeks), MTX + RES group (20 mg / kg ip, once a week and 40 mg / kg / day orally for 2 weeks)At the end of the experiment, blood samples were taken from the hearts of the rats and the percentage of leukocyte (neutrophil, eosinophil, basophil, lymphocyte, monocyte) was examined by classical methods. The levels of TOS and TAS were measured by colorimetric kits and 8-OHDG level by ELISA kit. Neutrophil (p≤0.05) and monocyte (p≤0.01) percentages of MTX and MTX + RES groups were found to be statistically lower than control and RES groups. There was also a significant increase in TOS and OSI levels (p
Reference67 articles.
1. Abdel-Wahaba BA, Abdel-Wahab MM (2016). Protective effect of resveratrol against chronic intermittent hypoxia-induced spatial memory deficits, hippocampal oxidative DNA damage and increased p47Phox NADPH oxidase expression in young rats. Behav Brain Res, 305, 65–75.
2. Aggrawal B, Shishodia S (2005). Resveratrol: A polyphenol for all season. Resveratrol in Health and Disease. University of Texas M. D. Anderson Cancer Center, CRC Press, Taylor and Francis group, 1, 70, 1-16.
3. Akkuş Ö, Şanlı K (2006). Kanserli çocuklarda hemşirelik bakımı ve desteğinin önemi. Uyar M, Uslu R, Yıldırım Y.K, editör. Kanser ve palyatif bakım. İzmir: Meta Basım Matbaacılık, 309-19.
4. Alturfan AA, Tozan-Beceren A, Sehirli AO, Demiralp E, Sener G, Omurtag GZ (2011). Resveratrol ameliorates oxidative DNA damage and protects against acrylamide-induced oxidative stress in rats. Mol Biol Rep, 39, 4, 4589-4596.
5. Aribal-Kocatürk P, Kavas GÖ, Büyükkağnıcı Dİ (2007). Pretreatment effect of resveratrol on streptozotocin-induced diabetes in rats. Biol Trace Elem Res, 118, 3, 244–249.
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