Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice-Reference-Cited by-同舟云学术

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Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice

Published:2012-12-10 Issue:1 Volume:123 Page:335-339
ISSN:0021-9738
Container-title:Journal of Clinical Investigation
language:en
Short-container-title:J. Clin. Invest.

Author:

Chang Tiffany,Krisman Kimberly,Theobald Emily Harding,Xu Jin,Akutagawa Jon,Lauchle Jennifer O.,Kogan Scott,Braun Benjamin S.,Shannon Kevin

Publisher

American Society for Clinical Investigation

Subject

General Medicine

Reference17 articles.

1. NF1 Tumor Suppressor Gene Function

2. Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemia

3. Homozygous Inactivation of theNF1Gene in Bone Marrow Cells from Children with Neurofibromatosis Type 1 and Malignant Myeloid Disorders

4. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

5. Targeting oncogenic Ras signaling in hematologic malignancies

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4. Therapeutic efficacy of RAS inhibitor trametinib using a juvenile myelomonocytic leukemia patient-derived xenograft model;Pediatric Hematology and Oncology;2024-04-22

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