Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice

Author:

Maganin Alexandre G.,Souza Guilherme R.,Fonseca Miriam D.ORCID,Lopes Alexandre H.,Guimarães Rafaela M.,Dagostin AndréORCID,Cecilio Nerry T.,Mendes Atlante S.ORCID,Gonçalves William A.,Silva Conceição E.A.,Fernandes Gomes Francisco Isaac,Mauriz Marques Lucas M.,Silva Rangel L.ORCID,Arruda Letícia M.,Santana Denis A.,Lemos HenriqueORCID,Huang LeiORCID,Davoli-Ferreira Marcela,Santana-Coelho Danielle,Sant’Anna Morena B.,Kusuda RicardoORCID,Talbot Jhimmy,Pacholczyk Gabriela,Buqui Gabriela A.,Lopes Norberto P.,Alves-Filho Jose C.ORCID,Leão Ricardo M.,O’Connor Jason C.,Cunha Fernando Q.,Mellor AndrewORCID,Cunha Thiago M.

Funder

FAPESP

Publisher

American Society for Clinical Investigation

Subject

General Medicine

Reference94 articles.

1. Neuropathic pain

2. Pain regulation by non-neuronal cells and inflammation

3. Pathological pain and the neuroimmune interface

4. Kynurenines in the mammalian brain: when physiology meets pathology;Schwarcz;Nat Rev Neurosci,2013

5. Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health;Cervenka;Science,2017

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