Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease
Author:
Funder
Bioverativ
Publisher
American Society for Clinical Investigation
Subject
General Medicine
Link
https://insight.jci.org/articles/view/96409/files/pdf
Reference54 articles.
1. Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions
2. Not simply misshapen red cells: multimolecular and cellular events in sickle vaso-occlusion
3. Heme Degradation and Vascular Injury
4. Extracellular hemin crisis triggers acute chest syndrome in sickle mice
5. Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease
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