SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation
Author:
Funder
NIDDK, NEI, Cystic Fibrosis Foundation, Cystic Fibrosis Research Inc.
Publisher
American Society for Clinical Investigation
Subject
General Medicine
Link
https://insight.jci.org/articles/view/121370/files/pdf
Reference48 articles.
1. Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas.
2. The down-regulated in adenoma (DRA) gene encodes an intestine-specific membrane glycoprotein;Byeon;Oncogene,1996
3. Mutations of the Down–regulated in adenoma (DRA) gene cause congenital chloride diarrhoea
4. Down-regulated in Adenoma Cl/HCO3 Exchanger Couples With Na/H Exchanger 3 for NaCl Absorption in Murine Small Intestine
5. Coupling Modes and Stoichiometry of Cl−/HCO3− Exchange by slc26a3 and slc26a6
Cited by 36 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Chitosan and its oligosaccharide accelerate colonic motility and reverse serum metabolites in rats after excessive protein consumption;International Journal of Biological Macromolecules;2023-12
2. A Novel Peptide Prevents Enterotoxin- and Inflammation-Induced Intestinal Fluid Secretion by Stimulating Sodium-Hydrogen Exchanger 3 Activity;Gastroenterology;2023-10
3. SLC26A3 (DRA) is stimulated in a synergistic, intracellular Ca2+-dependent manner by cAMP and ATP in intestinal epithelial cells;American Journal of Physiology-Cell Physiology;2023-06-01
4. Wenyang Yiqi Formula improves Na + /H + ion transport by inhibiting NHE3 via activation of gastrin/CCKBR pathway;2023-04-05
5. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action;European Journal of Medicinal Chemistry;2023-03
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3