Free light chains injure proximal tubule cells through the STAT1/HMGB1/TLR axis-Reference-Cited by-同舟云学术

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Free light chains injure proximal tubule cells through the STAT1/HMGB1/TLR axis

Published:2020-07-23 Issue:14 Volume:5 Page:
ISSN:2379-3708
Container-title:JCI Insight
language:en
Short-container-title:

Author:

Upadhyay Rohit^ORCID,Ying Wei-Zhong,Nasrin Zannatul,Safah Hana,Jaimes Edgar A.^ORCID,Feng Wenguang^ORCID,Sanders Paul W.^ORCID,Batuman Vecihi

Funder

Paul Teschan Research Fund

United States Department of Veterans Affairs Clinical Sciences R&D (CSRD) Service

National Institutes of Health George M. O’Brien Kidney and Urological Research Centers Program

Publisher

American Society for Clinical Investigation

Subject

General Medicine

Link

https://insight.jci.org/articles/view/137191/files/pdf

Reference41 articles.

1. The pathogenesis and diagnosis of acute kidney injury in multiple myeloma;Hutchison;Nat Rev Nephrol,2011

2. Proximal tubular injury in myeloma;Batuman;Contrib Nephrol,2007

3. Myeloma light chains are ligands for cubilin (gp280);Batuman;Am J Physiol,1998

4. Silencing megalin and cubilin genes inhibits myeloma light chain endocytosis and ameliorates toxicity in human renal proximal tubule epithelial cells

5. Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury

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