Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation-Reference-Cited by-同舟云学术

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Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation

Published:2023-09-08 Issue:17 Volume:8 Page:
ISSN:2379-3708
Container-title:JCI Insight
language:en
Short-container-title:

Author:

Chen Pan-Yu,Huang Benjamin J.^ORCID,Harris Max,Boone Christopher^ORCID,Wang Weijie^ORCID,Carias Heidi,Mesiona Brian,Mavrici Daniela,Kohler Amanda C.,Bollag Gideon,Zhang Chao,Zhang Ying^ORCID,Shannon Kevin^ORCID

Funder

Leukemia and Lymphoma Society

National Institutes of Health

Publisher

American Society for Clinical Investigation

Subject

General Medicine

Link

https://insight.jci.org/articles/view/168445/files/pdf

Reference52 articles.

1. RAS Proteins and Their Regulators in Human Disease

2. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

3. The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients

4. Diverse alterations associated with resistance to KRAS(G12C) inhibition

5. Acquired Resistance to KRASG12C Inhibition in Cancer

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1. Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket;Cell;2024-09

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