Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1
Author:
Funder
National Institutes of Health
Publisher
American Society for Clinical Investigation
Subject
General Medicine
Link
https://insight.jci.org/articles/view/131834/files/pdf
Reference67 articles.
1. The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
2. Beyond Mitophagy: Cytosolic PINK1 as a Messenger of Mitochondrial Health
3. Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects
4. Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
5. Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
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