Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis-Reference-Cited by-同舟云学术

Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis

Published:2003-12-01 Issue:11 Volume:112 Page:1678-1687
ISSN:0021-9738
Container-title:Journal of Clinical Investigation
language:en
Short-container-title:J. Clin. Invest.

Author:

Liu Yaping,Binz Jane,Numerick Mary Jo,Dennis Steve,Luo Guizhen,Desai Bhasha,MacKenzie Kathleen I.,Mansfield Traci A.,Kliewer Steven A.,Goodwin Bryan,Jones Stacey A.

Publisher

American Society for Clinical Investigation

Subject

General Medicine

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1. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis

2. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

3. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis

4. Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

5. Ursodeoxycholic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited

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