Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice-Reference-Cited by-同舟云学术

Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice

Published:2001-01-01 Issue:1 Volume:107 Page:35-44
ISSN:0021-9738
Container-title:Journal of Clinical Investigation
language:en
Short-container-title:J. Clin. Invest.

Author:

Neuhold Lisa A.,Killar Loran,Zhao Weiguang,Sung Mei-Li A.,Warner Linda,Kulik John,Turner James,Wu William,Billinghurst C.,Meijers T.,Poole A. Robin,Babij Philip,DeGennaro Louis J.

Publisher

American Society for Clinical Investigation

Subject

General Medicine

Reference50 articles.

1. Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.

2. Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay.

3. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

4. Evidence for altered synthesis of type II collagen in patients with osteoarthritis.

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