Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair-Reference-Cited by-同舟云学术

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Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

Published:2007-06-01 Issue:6 Volume:117 Page:1627-1636
ISSN:0021-9738
Container-title:Journal of Clinical Investigation
language:en
Short-container-title:J. Clin. Invest.

Author:

Little Christopher B.,Meeker Clare T.,Golub Suzanne B.,Lawlor Kate E.,Farmer Pamela J.,Smith Susan M.,Fosang Amanda J.

Publisher

American Society for Clinical Investigation

Subject

General Medicine

Reference65 articles.

1. Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain

2. N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage

3. Mechanism of catabolism of aggrecan by articular cartilage

4. The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.

5. The structure of aggrecan fragments in human synovial fluid. evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

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