SHP2 inhibition reduces leukemogenesis in models of combined genetic and epigenetic mutations
Author:
Funder
National Institute of Health
Riley Children’s Foundation
Ralph W. and Grace M. Showalter Research Trust Fund
Publisher
American Society for Clinical Investigation
Subject
General Medicine
Link
https://www.jci.org/articles/view/130520/files/pdf
Reference19 articles.
1. Prognostic factors for acute myeloid leukaemia in adults - biological significance and clinical use
2. Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies
3. Mutational Cooperativity Linked to Combinatorial Epigenetic Gain of Function in Acute Myeloid Leukemia
4. DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia
5. DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias
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