Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells

Author:

Sellar Rob S.,Sperling Adam S.ORCID,Słabicki MikołajORCID,Gasser Jessica A.,McConkey Marie E.,Donovan Katherine A.ORCID,Mageed Nada,Adams Dylan N.,Zou CharlesORCID,Miller Peter G.ORCID,Dutta Ravi K.,Boettcher SteffenORCID,Lin Amy E.ORCID,Sandoval Brittany,Quevedo Barrios Vanessa A.,Kovalcik Veronica,Koeppel JonasORCID,Henderson Elizabeth K.,Fink Emma C.ORCID,Yang Lu,Chan Anthony,Pokharel Sheela Pangeni,Bergstrom Erik J.ORCID,Burt Rajan,Udeshi Namrata D.ORCID,Carr Steven A.ORCID,Fischer Eric S.ORCID,Chen Chun-WeiORCID,Ebert Benjamin L.ORCID

Funder

NIH

Publisher

American Society for Clinical Investigation

Subject

General Medicine

Reference46 articles.

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2. Clinical activity of CC-90009, a cereblon E3 ligase modulator and first-in-class GSPT1 degrader, as a single agent in patients with relapsed or refractory acute myeloid leukemia (R/R AML): first results from a phase I dose-finding study;Uy;Blood,2019

3. CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells;Surka;Blood,2020

4. Human Eukaryotic Release Factor 3a Depletion Causes Cell Cycle Arrest at G 1 Phase through Inhibition of the mTOR Pathway

5. GTP Hydrolysis by eRF3 Facilitates Stop Codon Decoding during Eukaryotic Translation Termination

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