The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy-Reference-Cited by-同舟云学术

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

Published:2009-04-01 Issue:4 Volume:119 Page:964-975
ISSN:0021-9738
Container-title:Journal of Clinical Investigation
language:en
Short-container-title:J. Clin. Invest.

Author:

Montini Eugenio,Cesana Daniela,Schmidt Manfred,Sanvito Francesca,Bartholomae Cynthia C.,Ranzani Marco,Benedicenti Fabrizio,Sergi Lucia Sergi,Ambrosi Alessandro,Ponzoni Maurilio,Doglioni Claudio,Di Serio Clelia,von Kalle Christof,Naldini Luigi

Publisher

American Society for Clinical Investigation

Subject

General Medicine

Reference67 articles.

1. Stem cell clonality and genotoxicity in hematopoietic cells: Gene activation side effects should be avoidable

2. Side effects of retroviral gene transfer into hematopoietic stem cells

3. A Serious Adverse Event after Successful Gene Therapy for X-Linked Severe Combined Immunodeficiency

4. Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1

5. Importance of Murine Study Design for Testing Toxicity of Retroviral Vectors in Support of Phase I Trials

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