Author:
Li Chentong, ,Xu Jinhu,Liu Jiawei,Zhou Yicang, ,
Abstract
<abstract>
<p>In this work, we use a within-host viral dynamic model to describe the SARS-CoV-2 kinetics in the host. Chest radiograph score data are used to estimate the parameters of that model. Our result shows that the basic reproductive number of SARS-CoV-2 in host growth is around 3.79. Using the same method we also estimate the basic reproductive number of MERS virus is 8.16 which is higher than SARS-CoV-2. The PRCC method is used to analyze the sensitivities of model parameters. Moreover, the drug effects on virus growth and immunity effect of patients are also implemented to analyze the model.</p>
</abstract>
Publisher
American Institute of Mathematical Sciences (AIMS)
Subject
Applied Mathematics,Computational Mathematics,General Agricultural and Biological Sciences,Modelling and Simulation,General Medicine
Reference21 articles.
1. J. T. Wu, K. Leung, G. M. Leung, Nowcasting and forecasting the potential domestic and international spread of the 2019-ncov outbreak originating in wuhan, china: a modelling study, Lancet, 2020.
2. S. F. Ahmed, A. A. Quadeer, M. R. McKay, Preliminary identification of potential vaccine targets for the covid-19 coronavirus (sars-cov-2) based on sars-cov immunological studies, Viruses, 12 (2020), 254.
3. H. W. Elsland, Y. Wang, Report 5: Phylogenetic analysis of sars-cov-2.
4. W. Shang, Y. Yang, Y. Rao, X. Rao, The outbreak of sars-cov-2 pneumonia calls for viral vaccines, npj Vaccines, 5 (2020), 1-3.
5. F. Pan, T. Ye, P. Sun, S. Gui, B. Liang, L. Li, et al., Time course of lung changes on chest ct during recovery from 2019 novel coronavirus (covid-19) pneumonia, Radiology, (2020), 200370.
Cited by
72 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献