Anti-inflammatory and antioxidant properties of bark and fruit extracts of Faidherbia albida (Delile) A. Chev: A perspective from bio-prospecting assays to scientometric approach-Reference-Cited by-同舟云学术

Anti-inflammatory and antioxidant properties of bark and fruit extracts of Faidherbia albida (Delile) A. Chev: A perspective from bio-prospecting assays to scientometric approach

Published:2024 Issue:3 Volume:11 Page:262-276
ISSN:2372-0301
Container-title:AIMS Molecular Science
language:
Short-container-title:AIMSMOLES

Author:

Abdelwahab Siddig Ibrahim¹,Taha Manal Mohamed Elhassan¹,Al-Zubairi Adel S.²³,Syahida Ahmad⁴⁵,KaHeng Lee⁴⁵,Narrima Putri⁶,Othman Rozana⁷,Alfaifi Hassan Ahmad⁸,Alzahrani Amal Hamdan⁹

Affiliation:

1. Medical Research Centre, Jazan University, Jazan, 82817, Saudi Arabia

2. Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi Arabia

3. Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen

4. Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

5. Institute of Biosciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

6. Department of Pharmacology, University of Malaya, Kuala Lumpur, Malaysia

7. College of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia

8. Pharmaceutical Care Administration (Jeddah Second Health Cluster), Ministry of Health, Saudi Arabia

9. Department of Pharmacology and Toxicology, College of Pharmacy, King Abdulaziz University, Saudi Arabia

Abstract

<italic>Faidherbia albida (Delile) A. Chev</italic>, a type of tree in the Leguminosae family, has several traditional uses. This study investigates the antioxidant properties, phenolic and flavonoid contents, nitric acid modulatory effects, and cytotoxicity of methanolic and chloroform extracts of the bark and fruits of <italic>Faidherbia albida</italic>. Various assays were performed to evaluate the antioxidant properties of the extracts, including the Folin-Ciocalteu and AlCl3 tests, the oxygen radical absorbance capacity (ORAC), the purple diphenyl picrylhydrazine (DPPH) scavenging ability, and the Ferric Reducing/Antioxidant Power (FRAP). The ability of the extracts to modulate the production of nitric oxide (NO) was assessed, and the cytotoxicity of the extracts was evaluated in cultured cells. Additionally, a bibliometric analysis was performed on related research documents. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to evaluate the cytotoxicity of the extracts in cultivated RAW 264.7 cells. A bibliometric analysis of 362 research documents related to <italic>F. albida</italic> published since 1913 was performed to understand the current state of knowledge to identify areas for further research using bibliometric computer packages. The results showed that the bark methanolic extract had the highest phenolic content, while the chloroform extract of the fruits had the highest flavonoid content. The chloroform extract of the fruits exhibited the highest inhibition of NO production. The extracts exhibited low cytotoxicity. The methanolic extract of the bark exhibited the strongest radical scavenging activities for FRAP and DPPH. The ORAC assay revealed that the antioxidant capacity of the methanolic extract of the fruits and the chloroform extract of the bark were approximately four times greater than that of quercetin, which is a known antioxidant compound. <italic>F. albida</italic> exhibits a significant antioxidant activity, which is influenced by both solvent polarity and specific botanical components.

Publisher

American Institute of Mathematical Sciences (AIMS)

Reference37 articles.