Modelling the spatial spread of COVID-19 in a German district using a diffusion model

Abstract

<abstract><p>In this study, we focus on modeling the local spread of COVID-19 infections. As the pandemic continues and new variants or future pandemics can emerge, modelling the early stages of infection spread becomes crucial, especially as limited medical data might be available initially. Therefore, our aim is to gain a better understanding of the diffusion dynamics on smaller scales using partial differential equation (PDE) models. Previous works have already presented various methods to model the spatial spread of diseases, but, due to a lack of data on regional or even local scale, few actually applied their models on real disease courses in order to describe the behaviour of the disease or estimate parameters. We use medical data from both the Robert-Koch-Institute (RKI) and the Birkenfeld district government for parameter estimation within a single German district, <italic>Birkenfeld</italic> in Rhineland-Palatinate, during the second wave of the pandemic in autumn 2020 and winter 2020–21. This district can be seen as a typical middle-European region, characterized by its (mainly) rural nature and daily commuter movements towards metropolitan areas. A basic reaction-diffusion model used for spatial COVID spread, which includes compartments for susceptibles, exposed, infected, recovered, and the total population, is used to describe the spatio-temporal spread of infections. The transmission rate, recovery rate, initial infected values, detection rate, and diffusivity rate are considered as parameters to be estimated using the reported daily data and least square fit. This work also features an emphasis on numerical methods which will be used to describe the diffusion on arbitrary two-dimensional domains. Two numerical optimization techniques for parameter fitting are used: the Metropolis algorithm and the adjoint method. Two different methods, the Crank-Nicholson method and a finite element method, which are used according to the requirements of the respective optimization method are used to solve the PDE system. This way, the two methods are compared and validated and provide similar results with good approximation of the infected in both the district and the respective sub-districts.</p></abstract>