The influence of immune cells on the existence of virus quasi-species

Abstract

<abstract><p>This article investigate a nonlocal reaction-diffusion system of equations modeling virus distribution with respect to their genotypes in the interaction with the immune response. This study demonstrates the existence of pulse solutions corresponding to virus quasi-species. The proof is based on the Leray-Schauder method, which relies on the topological degree for elliptic operators in unbounded domains and a priori estimates of solutions. Furthermore, linear stability analysis of a spatially homogeneous stationary solution identifies the critical conditions for the emergence of spatial and spatiotemporal structures. Finally, numerical simulations are used to illustrate nonlinear dynamics and pattern formation in the nonlocal model.</p></abstract>