The Protective Effect of Caffeic acid Phenethyl Ester on Cadmiyum-induced Liver Toxicity: A Histopathological and Biochemical Study-Reference-Cited by-同舟云学术

The Protective Effect of Caffeic acid Phenethyl Ester on Cadmiyum-induced Liver Toxicity: A Histopathological and Biochemical Study

Published:2022-05-31 Issue: Volume: Page:
ISSN:1300-0861
Container-title:Ankara Üniversitesi Veteriner Fakültesi Dergisi
language:en
Short-container-title:Ankara Univ Vet Fak Derg

Author:

DEVECİ Haci Ahmet¹,NUR Gökhan²,KÜKÜRT Abdulsamed³,KURU Mushap⁴,DEVECİ Ayla⁵

Affiliation:

1. GAZIANTEP UNIVERSITY, FACULTY OF HEALTH SCIENCES, DEPARTMENT OF NUTRITION AND DIETETICS, DEPARTMENT OF NUTRITION AND DIETETICS

2. ISKENDERUN TECHNICAL UNIVERSITY, FACULTY OF ENGINEERING AND NATURAL SCIENCES, DEPARTMENT OF BIOMEDICAL ENGINEERING, BIOMEDICAL ENGINEERING PR.

3. KAFKAS UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF BASIC SCIENCES VETERINARY MEDICINE

4. KAFKAS UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF CLINICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNECOLOGY

5. KILIS 7 ARALIK UNIVERSITY, VOCATIONAL HIGHER SCHOOL OF TECHNICAL SCIENCES

Abstract

In this study, the changes caused by caffeic acid phenethyl ester (CAPE) in the histopathological and biochemical parameters in the oxidant / antioxidant balance in mice with experimental cadmium toxicity were investigated. Plasma paraoxonase (PON) activity, high-density lipoprotein (HDL), low density lipoprotein (LDL), total sialic acid (TSA), total antioxidant capacity (TAC), total oxidant capacity (TOC), and oxidative stress index (OSI) were analyzed on mice’s blood samples. The results showed that cadmium intoxication triggered oxidative stress in the mice. It also lowered their PON activity alongside TAC and HDL levels and increased their TSA, LDL, TOC, and OSI levels. The histopathological examination of the liver tissues revealed focal apoptotic regions, sinusoidal occlusion, and irregularity in the cadmium group and no significant change in the other groups. These results indicated that CAPE can significantly prevent biochemical and histopathological changes due to cadmium damage.

Publisher

Veterinary Journal of Ankara University

Subject

General Veterinary,Animal Science and Zoology

Reference49 articles.

1. 1. Aviram M, Rosenblat M, Bisgaier CL et al (1998): Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions: A possible peroxidative role for paraoxonase. J Clin Invest, 101, 1581-1590.

2. 2. Banskota AH, Tezuka Y, Kadota S (2001): Recent progress in pharmacological research of propolis. Phyther Res, 15, 561-571.

3. 3. Bashir N, Manoharan V, Prabu SM (2014): Cadmium Toxicity: Oxidative Stress and Organ Dysfunction. STM Journals, 4, 1-19.

4. 4. Borrelli F, Maffia P, Pinto L et al (2002): Phytochemical compounds involved in the anti-inflammatory effect of propolis extract. Fitoterapia, 73, 53-63.

5. 5. Brzóska MM, Kamiński M, Supernak-Bobko D et al (2003): Changes in the structure and function of the kidney of rats chronically exposed to cadmium. I. Biochemical and histopathological studies. Arch Toxicol, 77, 344-352.

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Kadmiyum Klorür Toksisitesinin Karaciğer, Böbrek ve Pankreasta Neden Olduğu Hasarı Melatonin Önler mi?;Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi;2023-12-01