1. Department of Psychiatry, Harvard Medical School, Boston, MA, USA (Tondo, Baldessarini); International Consortium for Mood & Psychotic Disorder Research, McLean Hospital, Belmont, MA, USA (all authors); Lucio Bini Mood Disorder Centers, Cagliari and Rome, Italy (Tondo); Department of Psychiatry, Queen’s University School of Medicine, Kingston, Ontario, Canada (Vazquez).