Isoniazid-Induced Severe Hepatotoxicity: An Infrequent but Preventable Cause of Liver Failure in Children Treated for Latent Tuberculosis Infection

Author:

Desrochers Dan1,González-Peralta Regino P.2,McClenathan Daniel T.1,Wilsey Michael J.1,Haafiz Allah2

Affiliation:

1. Department of Pediatrics, University of South Florida College of Medicine, Tampa, Florida, USA.

2. Pediatric Hepatology and Liver Transplantation, Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Florida College of Medicine and Shands Children's Hospital, Gainesville, Florida, USA.

Abstract

Isoniazid (INH) monotherapy has gained widespread acceptance as an efficacious therapy for latent tuberculosis infection (LTBI) especially in low-prevalence settings. Although INH related hepatotoxicity is well recognized, progression to severe liver dysfunction requiring care at a transplant center remains unpredictable. We report the management of a five year-old girl who developed progressive liver failure due to INH prophylaxis. This highlights the potential severity of INH related hepatic injury and underscores the significance of vigilant clinical monitoring throughout the duration of the therapy in children.

Publisher

SAGE Publications

Subject

Media Technology

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