The Comparative Genomics and Phylogenomics of Leishmania Amazonensis Parasite-Reference-Cited by-同舟云学术

The Comparative Genomics and Phylogenomics of Leishmania Amazonensis Parasite

Published:2014-01 Issue: Volume:10 Page:EBO.S13759
ISSN:1176-9343
Container-title:Evolutionary Bioinformatics
language:en
Short-container-title:Evol Bioinform Online

Author:

Tschoeke Diogo A.¹²,Nunes Gisele L.²,Jardim Rodrigo¹²,Lima Joana²,Dumaresq Aline S. R.²,Gomes Monete R.²,De Mattos Pereira Leandro²,Loureiro Daniel R.¹,Stoco Patricia H.³,De Matos Gliedes Herbert Leonel⁴⁵,De Miranda Antonio Basilio¹²,Ruiz Jeronimo¹⁶,Pitaluga André⁷,Silva Floriano P.¹⁸,Probst Christian M.¹⁹,Dickens Nicholas J.⁵,Mottram Jeremy C.⁵,Grisard Edmundo C.³,Dávila Alberto M. R.¹²

Affiliation:

1. Pólo de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz (Fiocruz/IOC), Rio de Janeiro, RJ, Brazil.

2. Laboratório de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

3. Laboratório de Protozoologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

4. Laboratório de Inflamação Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

5. Wellcome Trust Centre for Molecular Parasitology, Institute of Immunity, Infection and Inflammation, College of MVLS, University of Glasgow, Glasgow, UK.

6. Instituto René Rachou (Fiocruz/IRR), Belo Horizonte, MG, Brazil.

7. Laboratório de Biologia Molecular de Parasitas e Vetores, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

8. Laboratório de Bioquímica de Proteínas e Peptídeos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

9. Instituto Carlos Chagas (Fiocruz/ICC), Curitiba, PR, Brazil.

Abstract

Leishmaniasis is an infectious disease caused by Leishmania species. Leishmania amazonensis is a New World Leishmania species belonging to the Mexicana complex, which is able to cause all types of leishmaniasis infections. The L. amazonensis reference strain MHOM/BR/1973/M2269 was sequenced identifying 8,802 codifying sequences (CDS), most of them of hypothetical function. Comparative analysis using six Leishmania species showed a core set of 7,016 orthologs. L. amazonensis and Leishmania mexicana share the largest number of distinct orthologs, while Leishmania braziliensis presented the largest number of inparalogs. Additionally, phylogenomic analysis confirmed the taxonomic position for L. amazonensis within the “Mexicana complex”, reinforcing understanding of the split of New and Old World Leishmania. Potential non-homologous isofunctional enzymes (NISE) were identified between L. amazonensis and Homo sapiens that could provide new drug targets for development.

Publisher

SAGE Publications

Subject

Computer Science Applications,Genetics,Ecology, Evolution, Behavior and Systematics

Link

http://journals.sagepub.com/doi/pdf/10.4137/EBO.S13759

Cited by 21 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Complete assembly, annotation of virulence genes and CRISPR editing of the genome of Leishmania amazonensis PH8 strain;Genomics;2023-09

2. ACW-02 an Acridine Triazolidine Derivative Presents Antileishmanial Activity Mediated by DNA Interaction and Immunomodulation;Pharmaceuticals;2023-01-29

3. Subtilisin of Leishmania amazonensis as Potential Druggable Target: Subcellular Localization, In Vitro Leishmanicidal Activity and Molecular Docking of PF-429242, a Subtilisin Inhibitor;Current Issues in Molecular Biology;2022-05-09

4. In silico analysis of Leishmania proteomes and protein-protein interaction network: Prioritizing therapeutic targets and drugs for repurposing to treat leishmaniasis;Acta Tropica;2022-05

5. New Insights into the Mechanism of Action of the Cyclopalladated Complex (CP2) in Leishmania : Calcium Dysregulation, Mitochondrial Dysfunction, and Cell Death;Antimicrobial Agents and Chemotherapy;2022-01-18