Characterization of Alkylbenzene Sulfonate Inhibitors of Rat Brain Calcineurin Activity

Author:

Ito Noboru,Hosaka Kohei,Tokita Yoshiharu,Nakajima-Shimada Junko,Takahashi Chiyuki,Tanaka Susumu

Publisher

Kitakanto Medical Society

Subject

General Medicine

Reference11 articles.

1. 2. Yu L, Golbeck J, Yao J, et al. Spectroscopic and enzymatic characterization of the active site dinuclear metal center of calcineurin, implications for a mechanistic role. Biochemistry 1997; 36: 10727-10734.

2. 3. Gong CX, Singh TJ, Grundke IK, Alzheimer's disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase-2B (calcineurin). J Neurochem 1994; 62: 803-806.

3. 4. Garver TD, Kincaid RL, Conn RA, et al. Reduction of calcineurin activity in brain by antisense oligo-nucleotides leads to persistent phosphorylation of tau protein Thr181 and Thr231. Mol Pharmcol 1999; 55: 632-641.

4. 5. Liu J, Farmer JD, Lane WS, et al. Calcineurin is a common target of cyclophilin cyclosporin A and FKBP-PK506 complexes. Cell 1991; 66: 807-815.

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