Angiodestruction and Tissue Necrosis of Skin-Involving CD56+ NK/T-Cell Lymphoma Are Influenced by Expression of Cell Adhesion Molecules and Cytotoxic Granule and Apoptosis-Related Proteins

Author:

Takeshita Morishige1,Yamamoto Masahiro1,Kikuchi Masahiro2,Kimura Nobuhiro3,Nakayama Jyuichiro4,Uike Naokuni5,Daimaru Hiroshi6,Sawada Hitoshi7,Okamura Takashi8

Affiliation:

1. Departments of Pathology and Clinical Research, National Kyushu Medical Center Hospital, Fukuoka

2. Departments of Pathology, Fukuoka University, Fukuoka

3. Internal Medicine, Fukuoka University, Fukuoka

4. Dermatology, School of Medicine, Fukuoka University, Fukuoka

5. Department of Hematology, National Hospital Kyushu Cancer Center, Fukuoka

6. Department of Pathology, Hiroshima General Hospital, Hiroshima

7. Department of Internal Medicine, Kokura Memorial Hospital, Kitakyushu, Kyushu University, Fukuoka, Japan

8. Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Publisher

Oxford University Press (OUP)

Subject

General Medicine

Reference40 articles.

1. Bianchi G, Sironi M, Ghibaudi E, et al. Migration of natural killer cells across endothelial cell monolayer. J Immunol. 1993;151:5135-5144.

2. Aronson FR, Peter L, Brandon EP, et al. IL-2 rapidly induces natural killer cell adhesion to human endothelial cells. J Immunol. 1988;141:158-163.

3. Medley QG, Kedersha N, O'Brien S, et al. Characterization of GP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition. Proc Natl Acad Sci U S A. 1996;93:685-689.

4. Hameed A, Olsen KJ, Cheng L, et al. Immunohistologic identification of cytotoxic lymphocytes using human perforin monoclonal antibody. Am J Pathol. 1992;140:1025-1030.

5. Simon MM, Hausmann M, Tran T, et al. In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells. J Exp Med. 1997;186:1781-1786.

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