Cytogenetic and Flow Cytometry Evaluation of Richter Syndrome Reveals MYC, CDKN2A, IGH Alterations With Loss of CD52, CD62L and Increase of CD71 Antigen Expression as the Most Frequent Recurrent Abnormalities

Author:

Woroniecka Renata1,Rymkiewicz Grzegorz2,Grygalewicz Beata1,Błachnio Katarzyna2,Rygier Jolanta1,Jarmuż-Szymczak Małgorzata34,Ratajczak Błażej3,Pieńkowska-Grela Barbara1

Affiliation:

1. Cancer Genetics Laboratory of the Pathology Department and Laboratory Diagnostics, the Maria Skłodowska-Curie Memorial Institute and Cancer Centre, Warszawa, Poland

2. Flow Cytometry Laboratory of the Pathology Department and Laboratory Diagnostics, the Maria Skłodowska-Curie Memorial Institute and Cancer Centre, Warszawa, Poland

3. Department of Hematology and Bone Marrow Transplantation, University of Medical Sciences, Poznań, Poland

4. Institute of Human Genetics, Polish Academy of Sciences, Poznań, Poland.

Publisher

Oxford University Press (OUP)

Subject

General Medicine

Reference45 articles.

1. Richter syndrome: biology, incidence, and therapeutic strategies;Tsimberidou;Cancer,2005

2. Chronic lymphocytic leukaemia/small lymphocytic lymphoma;Müller-Hermelink,2008

3. Diffuse large B-cell lymphoma, not otherwise specified;Stein,2008

4. Clinical outcomes and prognostic factors in patients with Richter’s syndrome treated with chemotherapy or chemoimmunotherapy with or without stem-cell transplantation;Tsimberidou;J Clin Oncol,2006

5. Richter syndrome: a review of clinical, ocular, neurological and other manifestations;Omonti;Br J Haematol,2008

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