Rapid Diagnosis of Acute Promyelocytic Leukemia by Analyzing the Immunocytochemical Pattern of the PML Protein With the Monoclonal Antibody PG-M3

Author:

Villamor Neus1,Costa Dolors1,Aymerich Marta1,Esteve Jordi1,Carrió Anna1,Rozman Maria1,Aguilar Josep-Lluis1,Falini Brunangelo2,Montserrat Emili1,Campo Elias1,Colomer Dolors1

Affiliation:

1. Unitat d’Hematopatologia, Departments of Pathology and Hematology, Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Postgraduate School of Hematology Farreras-Valentí, Universitat de Barcelona. Barcelona, Spain

2. Institute of Hematology, University of Perugia, Perugia, Italy

Publisher

Oxford University Press (OUP)

Subject

General Medicine

Reference40 articles.

1. Bennett JM, Catovsky D, Daniel M-T, et al. Proposed revised criteria for the classification of acute myeloid leukemia. Ann Intern Med. 1985;103:620-625.

2. Orfao A, Chillón MC, Bortoluci AM, et al. The flow cytometric pattern of CD34, CD15 and CD13 expression in acute myeloblastic leukemia is highly characteristic of the presence of PML-RARalpha gene rearrangements. Haematologica. 1999;84:405-412.

3. Lo Coco FL, Nervi C, Avvisati G, et al. Acute promyelocytic leukemia: a curable disease. Leukemia. 1998;12:1866-1880.

4. Gogineni SK, Shah HO, Chester M, et al. Variant complex translocations involving chromosomes 1, 9, 9, 15 and 17 in acute promyelocytic leukemia without RAR alpha/PML gene fusion rearrangement. Leukemia. 1997;11:514-518.

5. Koken MH, Puvion-Dutilleul F, Guillemin MC, et al. The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion. EMBO J. 1994;13:1073-1083.

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