A Scoping Review of Role of Red Cell Width Distribution-To-Platelet Count Ratio in Neurological Disorders

Abstract

There is increasing role of routine laboratory parameters in identifying neuroinflammation in various neurological disorders. This has led to the need to identify reliable, accessible, and cost-effective biomarkers that can help predict the outcome following injury to the brain. The parameters of interest include a neutrophil-to-lymphocyte ratio (NLR), red cell width distribution (RDW), red cell width (RDW)-to-platelet ratio (RPR), and NLR times RPR (NLTRP). The aim of the present systematic review and meta-analysis is to evaluate the prognostic value of Red Cell Distribution Width to Platelet Count Ratio (RPR) in various neuropsychiatric disorders. The studies that reported "Red Cell Distribution Width to Platelet Count Ratio" and "Outcome" in neurological conditions and the full text was published in English were included in the systematic review and if the studies two or more than two a further metanalysis was performed. Two investigators performed the literature search that included PubMed, COCHRANE, SCOPUS, and ScienceDirect (from inception to June 8th 2022). The full text of the shortlisted articles was reviewed, and the articles were included based on our inclusion and exclusion criteria. Search resulted in 293 records, and after removing the duplicates, total five studies were found to be eligible to be included in the systematic review. After analysing the full text, five studies were excluded; out of these four studies described only red cell width distribution but did not mention the details of red cell width distribution-to-platelet distribution ratio and one study had methodology like described in another article (with smaller sample size and the same source of data) by same authors. Haematological parameters are promising predictor of mortality for acute TBI, overall survival (OS) in Glioma, affective disorders, predicting outcome in deep seated ICH.