A New Nonhydrolyzable Reactive cAMP Analog, (Sp)-Adenosine-3′,5′-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate Irreversibly Inactivates Human Platelet cGMP-Inhibited cAMP Phosphodiesterase-Reference-Cited by-同舟云学术

A New Nonhydrolyzable Reactive cAMP Analog, (Sp)-Adenosine-3′,5′-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate Irreversibly Inactivates Human Platelet cGMP-Inhibited cAMP Phosphodiesterase

Published:2002-02 Issue:1 Volume:30 Page:16-31
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Hung Su H.,Madhusoodanan K.S.,Beres James A.,Boyd Robert L.,Baldwin James L.,Zhang Wei,Colman Robert W.,Colman Roberta F.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference30 articles.

1. Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs)

2. Human platelet cGI-PDE: expression in yeast and localization of the catalytic domain by deletion mutagenesis

3. Conserved amino acids in metal-binding motifs of PDE3A are involved in substrate and inhibitor binding

4. Partial Characterization of the Active Site Human Platelet cAMP Phosphodiesterase, PDE3A, by Site-Directed Mutagenesis

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