Biotransformation of Perchloroethene: Dose-Dependent Excretion of Trichloroacetic Acid, Dichloroacetic Acid, andN-acetyl-S-(trichlorovinyl)-l-Cysteine in Rats and Humans after Inhalation

Author:

Völkel Wolfgang,Friedewald Marion,Lederer Elke,Pähler Axel,Parker Jean,Dekant Wolfgang

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference31 articles.

1. Quantitation of the tetrachloroethylene metaboliteN-acetyl-S-(trichlorovinyl)cysteine in rat urine via negative ion chemical ionization gas chromatography/tandem mass spectrometry;Bartels;Biol. Mass Spectrom.,1994

2. Biotransformation of trichloroethene: dose-dependent excretion of 1,1,1-trichloro-metabolites and mercapturic acids in rats and humans after inhalation;Bernauer;Arch. Toxicol.,1996

3. Metabolism of tetrachloroethene in rats: Identification ofNϵ-(dichloroacetyl)-L-lysine andNϵ-(trichloroacetyl)-L-lysine as protein adducts;Birner;Chem. Res. Toxicol.,1994

4. N-Acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine and 2,2,2-trichloroethanol: Two novel metabolites of tetrachloroethene in humans after occupational exposure;Birner;Drug Metab. Dispos.,1996

5. Enzymology of cysteineS-conjugate β-lyases;Cooper;Adv. Pharmacol.,1994

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