Wild-Type Enzyme as a Reporter of Inhibitor Binding by Catalytically Impaired Mutant Enzymes
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry,Biophysics
Reference14 articles.
1. Catalytic Mechanism of Scytalone Dehydratase: Site-Directed Mutagenisis, Kinetic Isotope Effects, and Alternate Substrates
2. Trihydroxynaphthalene Reductase from Magnaporthe grisea: Realization of an Active Center Inhibitor and Elucidation of the Kinetic Mechanism
3. Crystal structure of scytalone dehydratase — a disease determinant of the rice pathogen, Magnaporthe grisea
4. Structure-Based Design of Potent Inhibitors of Scytalone Dehydratase: Displacement of a Water Molecule from the Active Site
5. High-resolution structures of scytalone dehydratase-inhibitor complexes crystallized at physiological pH
Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Tight Binding Inhibition;Evaluation of Enzyme Inhibitors in Drug Discovery;2013-05-06
2. Roles of Substrate Distortion and Intramolecular Hydrogen Bonding in Enzymatic Catalysis by Scytalone Dehydratase;Biochemistry;2001-12-22
3. Determination of Serum Protein Binding Affinity of Inhibitors from Analysis of Concentration–Response Plots in Biochemical Activity Assays;Journal of Pharmaceutical Sciences;2000-08
4. Tight Binding Inhibitors of Scytalone Dehydratase: Effects of Site-Directed Mutations;Biochemistry;2000-06-27
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