Lazaroid compounds prevent early but not late stages of oxidant-induced cell injury: potential explanation for the lack of efficacy of lazaroids in clinical trials

Author:

Huang Hong,Patel Prakash B.,Salahudeen Abdulla K.

Publisher

Elsevier BV

Subject

Pharmacology

Reference23 articles.

1. Role of lipid peroxidation in H2O2-induced renal epithelial (LLC-PK1) cell injury;Salahudeen;Am J Physiol,1995

2. Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells;Salahudeen;J Am Soc Nephrol,1995

3. Attenuation of structural and functional damage from acute renal ischemia by the 21-amino steroid U74006F in rats;Podrazik;Curr Surg,1989

4. Effect of a 21-aminosteroid, U74006F, on lipid peroxidation and glomerulotubular function following experimental renal ischemia;Shackleton;J Surg Res,1994

5. Antioxidant lazaroid U-74006F improves renal function and reduces the expression of cytokines, inducible nitric oxide synthase, and MHC antigens in a syngeneic renal transplant model. Partial support for the response-to-injury hypothesis;Salahudeen;Transplantation,1996

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