The Pro12Ala Polymorphism in PPAR γ2 May Confer Resistance to Type 2 Diabetes

Author:

Hara Kazuo,Okada Terumasa,Tobe Kazuyuki,Yasuda Kazuki,Mori Yasumichi,Kadowaki Hiroko,Hagura Ryoko,Akanuma Yasuo,Kimura Satoshi,Ito Chikako,Kadowaki Takashi

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference17 articles.

1. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor;Tontonoz;Cell,1994

2. An antidiabetic thiazolidinedione is a higher affinity ligand for peroxisome proliferator-activated receptor-γ;Lehmann;J. Biol. Chem.,1995

3. PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance;Kubota;Molecular Cell,1999

4. PPARγ, the ultimate thrifty gene;Auwerx;Diabetologia,1999

5. Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians: Identification of a Pro12Ala PPAR γ 2 missense mutation;Yen;Biochem. Biophys. Res. Commun.,1997

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