Potential of Ribozymes against Deoxycytidine Kinase to Confer Drug Resistance to Cytosine Nucleoside Analogs

Author:

Beauséjour Christian M.,Tremblay Guy,Momparler Richard L.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference37 articles.

1. Transport and metabolism of deoxycytidine and 1-beta-d-arabinofuranosylcytosine into cultured Novikoff rat hepatoma cells, relationship to phosphorylation, and regulation of triphosphate synthesis;Plagemann;Cancer Res.,1978

2. Transfection of wild-type deoxycytidine kinase (dck) cDNA into an AraC- and DAC-resistant rat leukemic cell line of clonal origin fully restores drug sensitivity;Stegmann;Blood,1995

3. Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-beta-d-arabinofuranosylcytosine;Heinemann;Cancer Res.,1988

4. Improved prospects for long-term survival in adults with acute myelogenous leukemia;Keating;JAMA,1982

5. Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine);Hertel;Cancer Res.,1990

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