Direct Exposure of Mouse Ovaries and Oocytes to High Doses of an Adenovirus Gene Therapy Vector Fails to Lead to Germ Cell Transduction

Author:

Gordon Jon W.

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference21 articles.

1. Germline alteration by gene therapy: Assessing and reducing the risks;Gordon;Mol. Med. Today,1998

2. Adenoviral-mediated thymidine kinase gene transfer into the primate brain followed by systemic ganciclovir: Pathologic, radiologic, and molecular studies;Goodman;Hum. Gene Ther.,1996

3. Safety of intrapleurally administered recombinant adenovirus carrying herpes simplex thymidine kinase DNA followed by ganciclovir therapy in nonhuman primates;Kucharczuk;Hum. Gene Ther.,1996

4. Local inflammatory response and vector spread after direct intraprostatic injection of a recombinant adenovirus containing the herpes simplex virus thymidine kinase gene and ganciclovir therapy in mice;Timme;Cancer Gene Ther.,1998

5. Biodistribution of an adenoviral vector carrying the luciferase reporter gene following intravesical or intravenous administration to a mouse;Wood;Cancer Gene Ther.,1999

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