Strong Promoters Are the Key to Highly Efficient, Noninflammatory and Noncytotoxic Adenoviral-Mediated Transgene Delivery into the Brain in Vivo

Author:

Gerdes Christian A.,Castro Maria G.,Löwenstein Pedro R.

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference27 articles.

1. Human gene therapy;Anderson;Nature,1998

2. Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector;Blomer;J. Virol.,1997

3. Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials;Dewey;Nat. Med.,1999

4. The role of vector toxicity versus inflammatory and immune responses in eliminating adenovirus vector-mediated transgene expression from the rat brain;Thomas;Submitted,2000

5. Immune responses to adenovirus vectors in the nervous system;Wood;Trends Neurosci,1996

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