Cytotoxic Immune Response Blunts Long-Term Transgene Expression after Efficient Retroviral-Mediated Hepatic Gene Transfer in Rat

Author:

Aubert Dominique,Ménoret Séverine,Chiari Estelle,Pichard Virginie,Durand Sophie,Tesson Laurent,Moullier Philippe,Anegon Ignacio,Ferry Nicolas

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference48 articles.

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3. In vivo hepatic gene therapy—complete albeit transient correction of Factor IX deficiency in hemophilia B dogs;Kay;Proc. Natl. Acad. Sci. USA,1994

4. In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses;Kozarsky;J. Biol. Chem.,1994

5. Complete correction of hyperbilirubinemia in the Gunn rat model of Crigler–Najjar syndrome type I following transient in vivo adenovirus-mediated expression of human bilirubin UDP-glucuronosyl-transferase;Askari;Gene Ther.,1996

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