Multidimensional Gas Chromatography: Benefits and Considerations for Current and Prospective Users

Abstract

Two-dimensional gas chromatography (GC×GC) offers improved separation power for complex samples containing hundreds to thousands of analytes. However, several considerations must be made to determine whether multidimensional gas chromatography (MDGC) is the logical instrument choice to answer a particular scientific question, including, but not limited to, whether the analysis is targeted or non-targeted, the number of analytes of interest, and the presence of interferences that are coeluted, as well as any potential regulatory or industrial constraints. Currently, MDGC remains daunting for many users because of data complexity and the limited tools commercially available, which are critical for improving the accessibility of MDGC. Herein, we discuss considerations that may assist analysts, laboratory managers, regulatory agents, instrument and software vendors, and those interested in understanding the applicability of 2D-GC for the scientific question being investigated.