Small-Molecule Drug Discovery: Processes, Perspectives, Candidate Selection, and Career Opportunities for Analytical Chemists

Author:

Dong Michael W.1

Affiliation:

1. MWD Consulting

Abstract

This article provides an overview of the small-molecule drug discovery (SMDD) process for analytical scientists. The focus is on the modern approaches of identifying molecular targets, followed by high-throughput screening and synthesizing molecules with optimized properties for disease mitigation. The fundamental concepts and studies required in drug candidate selection, the business landscape, the technology trends, and the career opportunities for analytical chemists are discussed.

Publisher

Multimedia Pharma Sciences, LLC

Subject

Analytical Chemistry

Reference20 articles.

1. R.G. Hill and H.P. Rang, Eds., Drug Discovery and Development: Technology in Transition (Churchill Livingston, Edinburgh, UK, 2nd ed., 2012), chapters 4–11.

2. B.E. Blass, Basic Principles of Drug Discovery and Development (Academic Press, Cambridge, MA, 1st ed., 2015).

3. E.D. Zanders, The Science and Business of Drug Discovery: Demystifying the Jargon (Springer, Berlin, Germany, 2nd ed., 2020).

4. U. Nielsch, U. Fuhrmann, and S. Jaroch, Eds., New Approaches to Drug Discovery (Springer, Berlin, Germany, 1st ed., 2016).

5. M.W. Dong, “Drug Discovery and Development Processes,” Pittcon 2019 short course presented at Pittcon, Philadelphia, PA, 2019.

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