From Detector to Decision Part IV: Demystifying Peak Integration-Reference-Cited by-同舟云学术

From Detector to Decision Part IV: Demystifying Peak Integration

Published:2024-03-01 Issue: Volume: Page:24-26
ISSN:2996-9077
Container-title:LCGC International
language:en
Short-container-title:LCGC Int.

Author:

Snow Nicholas

Abstract

Most quantitative analysis in chromatography is performed based on the peak area, the integrated area underneath the curve defining a peak. There are many variables and settings in a data system that can impact this determination. In this installment, we will examine several of the common parameters that can affect automated peak integration and the resulting peak areas. We will consider how the data system detects the beginning and end of the peak, how it determines the peak maximum, how real peaks are differentiated from noise, and how signals at individual time intervals are summed to generate the peak area. We will also briefly look at techniques for determining the areas of unusually shaped peaks.

Publisher

Multimedia Pharma Sciences, LLC

Reference5 articles.

1. Snow, N. H. From Detector to Decision: How Does the GC Instrument Generate Your Data? LCGC North Am. 2020, 38 (9), 496–500.

2. Snow, N. H. How Can We Run a Gas Chromatograph from Anywhere? LCGC North Am. 2020, 38 (11), 601–605.

3. Snow, N. H. From Detector to Decision, Part III: Fundamentals of Calibration in Gas Chromatography. LCGC International 2024, 1 (1), 12–16.

4. Snow, N. H. Temperature Programmed GC: Why Are All Those Peaks So Sharp? LCGC North Am. 2019, 37 (7), 450–456.

5. Watson, D. The What, When, and How of Peak Integration: Part 1. What. CHROMacademy. https://www.chromacademy.com/channels/data-analysis/principles/the-what-when-and-how-of-peak-integration-part-i-what/ (accessed February, 2024).