Author:
Pomatsalyuk R.I.,Romanovsky S.K.,Shevchenko V.A.,Tenishev A.Eh.,Titov D.V.,Uvarov V.L.,Zakharchenko A.A.,Zhyglo V.Ph.
Abstract
Validation of process of medical product sterilization includes absorbed dose mapping in a phantom made of material representative of the object to be processed. Commonly, such measurements are carried out using the disposable chemical dosimeters placed in the phantom at the nodes of the 3D grid. Such a procedure is very laborious and costly in terms of the consumption of dosimeters. In the work, we investigated the possibility of using pyrometric method for prompt mapping of the absorbed dose. The studies were carried out using a rectangular phantom in the form of a set of expanded polystyrene plates, which is exposed to a scanned electron beam. The temperature and absorbed dose distributions in the phantom were measured. A linear dependence between them has been established. The calculation of the absorbed dose profile was also performed by MC simulations. Satisfactory agreement of the calculated dose distribution with the measured one is shown. The limitations of applicability of the proposed method are determined.
Publisher
Problems of Atomic Science and Technology
Reference11 articles.
1. ISO 11137-1:2006/Amd 2:2018 Sterilization of health care products – Radiation – Part 1: Requirements for development, validation and routine control of a sterilization process for medical devices.
2. ISO/ASTM 52303:2015 Guide for absorbed-dose mapping in radiation processing facilities. [Electronic resource] Verified 29.04.2021. URL: https://www.iso.org/ru/standard/67807.html
3. Ziaie, Farhood & Noori, Abbas. Investigation of high-dose irradiation effects on polystyrene calorimeter response // Nukleonika. 2006, v. 51, p. 175.
4. Arne Miller, Andras Kovacs. Calorimetry at industrial electron accelerators // Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 1985, v. 10-11, Part 2, p. 994-997.
5. U. Gaur and B. Wunderlich. Heat capacity and other thermodynamic properties of linear macromolecules. V. Polystyrene // Journal of Physical and Chemical Reference Data. 1982, v. 11, № 2, p. 313-325.