Predicting the systemic exposure and lung concentration of nafamostat using physiologically-based pharmacokinetic modeling
Author:
Affiliation:
1. Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Korea.
2. Research Institute of Pharmaceutical Sciences, College of Pharmacy, Woosuk University, Wanju 55338, Korea.
Funder
National Research Foundation of Korea
Ministry of Education
Publisher
Korean Society for Clinical Pharmacology and Therapeutics
Subject
Pharmacology (medical)
Link
https://tcpharm.org/pdf/10.12793/tcp.2022.30.e20
Reference28 articles.
1. Nafamostat and sepimostat identified as novel neuroprotective agents via NR2B N-methyl-D-aspartate receptor antagonism using a rat retinal excitotoxicity model
2. Continuous regional arterial infusion versus intravenous administration of the protease inhibitor nafamostat mesilate for predicted severe acute pancreatitis: a multicenter, randomized, open-label, phase 2 trial
3. An in Vivo Approach for Globally Estimating the Drug Flow between Blood and Tissue for Nafamostat Mesilate: the Main Hydrolysis Site Determination in Human
4. Synthesis and structure-activity study of protease inhibitors. IV. Amidinonaphthols and related acyl derivatives.
5. Involvement of Human Blood Arylesterases and Liver Microsomal Carboxylesterases in Nafamostat Hydrolysis
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