Vitamin D as the essential immunonutrient – the evidence base update: A review

Author:

Makarova Svetlana G.ORCID,Emelyashenkov Evgeny E.ORCID,Yasakov Dmitry S.ORCID,Pronina Irina Yu.ORCID,Ereshko Oksana A.ORCID,Gordeeva Irina G.ORCID,Galimova Albina A.ORCID,Chumbadze Tamara R.ORCID,Lebedeva Ayina M.ORCID

Abstract

The micronutrient status plays a key role for adequate immune response, including in diseases caused by respiratory viruses. Numerous studies conducted since the beginning of the COVID-19 pandemic, examining the impact of micronutrient availability, have shown their importance in the prevention of this disease. The largest number of publications is devoted to vitamin D. As a result, in less than two years, 17 meta-analyses and analytical reviews were published on the role of vitamin D and the availability of this micronutrient in various population groups in reducing the incidence, incidence of severe forms of COVID-19 and mortality. This review summarizes the results of published meta-analyses and systematic reviews. The analysis of literature data confirms that vitamin D has the highest evidence base as a micronutrient that reduces the risk of disease and the occurrence of severe forms of COVID-19. It also provides up-to-date recommendations on vitamin D supplementation for adult and pediatric patients.

Publisher

Consilium Medicum

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