Multiple myeloma with monoclonal immunoglobulin A exhibiting and hypercholesterolemia: case report and literature review

Abstract

Multiple myeloma with monoclonal immunoglobulin (Ig) A exhibiting is a type of the classic multiple myeloma, occurring every fifth patient. This type of disorder is associated with hypercholesterolemia that is refractory to the conventional therapy with anti-hyperlipidemic agents.This article presents a case of a patient B., 72 years old, whose disease debuted with high numbers of ESR and hypercholesterolemia. Ig Ak was identified by immunochemical analysis. Patient was diagnosed as having stage IA IgAk type multiple myeloma, diffuse lobular shape, with hyperlipidemia. Positive effect sustained after three courses of chemotherapy: level of IgA eventually subsided, and lipid metabolism returned to normal values.