Changes in markers of hematological, biochemical and coagulological blood tests with coronavirus COVID-19 infections

Abstract

This review provides new literature data on the features of changes in the indicators of clinical and biochemical analysis of blood, as well as hemostatic and fib-rinolysis systems in patients with coronavirus infection COVID-19. It was shown that laboratory manifestations of COVID-19 have their own characteristics and are closely interrelated with the nature of the course of infection. In a clinical blood test, lymphopenia and thrombocytopenia are most common. Among the bio-chemical parameters of blood, an increase in the level of C-reactive protein and ferritin, as well as a decrease in the level of albumin, are more often detected. It should be noted that in 1/3 of severe patients with COVID-19 infection, the activity of liver enzymes, ALT and AST, increases. Among the indicators of hemostasis and fibrinolysis systems, an increase in the concentration of D-dimer in blood plasma is more often detected. The review also analyzes the possible causes of changes in some laboratory parameters with COVID-19.