Abstract
In order to identify and correct concomitant diseases all patients undergo a comprehensive examination before surgical treatment. Rare concomitant diseases include primary chronic adrenal insufficiency. This clinical case presents the total duodenopancreatectomy in a patient with primary chronic adrenal insufficiency. Available algorithms are not always suitable in the treatment of such patients after surgical interventions, especially long-term and extensive. It is necessary to focus on laboratory parameters and the clinical picture. An individual and multidisciplinary approach to the treatment of patients with comorbid pathologies is important.