The role of laboratory biomarkers in monitoring of rituximab biosimilar therapy (Acellbia, “BIOCAD”) in patients with rheumatoid arthritis
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Published:2019-05-15
Issue:5
Volume:91
Page:26-33
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ISSN:2309-5342
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Container-title:Terapevticheskii arkhiv
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language:
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Short-container-title:Terapevticheskii arkhiv
Author:
Avdeeva A S,Cherkasova M V,Kusevich D A,Rybakova V V,Artyuhov A S,Dashinimaev Eh B,Chichasova N V,Nasonov E L
Abstract
Aim: to evaluate the role of laboratory biomarkers in monitoring effectiveness of rituximab (RTM) biosimilar therapy in a total dose of 1200 mg. Materials and methods. 20 patients (pts) with rheumatoid arthritis (RA) (18 woman, mean age 61.5(54-66.5) years, mean disease duration 39.5(20-84) months, mean DAS28 5.6(4.9-6.8)) received two intravenous RTM biosimilar infusions (600 mg №2) in combination with DMARDs and glucocorticoids. Laboratory biomarkers were assessed at baseline and weeks 12 and 24 after the first infusion of RTX. Results. RTM biosimilar induced decreases in DAS28, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) at week 12 and 24, p
Publisher
Consilium Medicum
Subject
General Medicine,Endocrinology, Diabetes and Metabolism,History,Family Practice
Reference57 articles.
1. Насонов Е.Л., Каратеев Д.Е., Балабанова Р.М. Ревматоидный артрит. В кн.: Ревматология. Национальное руководство. Под ред. Е.Л. Насонова, В.А. Насоновой. М.: ГЭОТАР-Медиа, 2008: 290-331.
2. Насонов Е.Л. Ритуксимаб. В кн.: Генно - инженерные биологические препараты в лечении ревматоидного артрита. Под ред. Е.Л. Насонова. М.: ИМА-ПРЕСС, 2013:200-221.
3. Huscher D, Mittendorf T, von Hinuber U, et al. Evolution of cost structures in rheumatoid arthritis over the past decade. Ann Rheum Dis. 2015;74(4):738-45. doi.org/10.1136/annrheumdis-2013-204311
4. BIOSIMILARS IN RHEUMATOLOGY
5. Федеральный закон от 22 декабря 2014 г. №429-ФЗ «О внесении изменений в Федеральный закон "Об обращении лекарственных средств"». Принят Государственной Думой 9 декабря 2014 г. Одобрен Советом Федерации 17 декабря 2014 г.