Prophylaxis of rhesus-sensitization of pregnant women. Experience of anti-rhesus immunoglobulin Rhesogam® N using

Author:

Nuriev Nail R.ORCID,Gabidullina Rushania I.ORCID,Galautdinova Diana I.ORCID

Abstract

Aim. Retrospective assessment of the efficiency and safety of the anti-rhesus Rh (D) immunoglobulin Rhesogam N in preventing isoimmunization in Rh-negative women during pregnancy. Materials and methods. An analysis of medical records of 196 Rh-negative patients who received anti-Rh immunoglobulin Rhesogam N in the period 20192021 was performed. The indications for the drug were the aspiration of chorionic villi, amniocentesis and prenatal prophylaxis in women with negative level of anti-Rh antibodies and in the case of Rh-positive husbands. Results. In total, 227 doses of the anti-rhesus immunoglobulin Rhesogam N were administered, including those women who underwent invasive procedures (aspiration of chorionic villi, amniocentesis). There were no adverse events, including anaphylaxis or drug-related events. 172 rhesus-positive babies were born. No cases of hemolityc disease of the newborns were reported. Anti-Rh antibodies were not found in their mothers after childbirth. Conclusion. The study confirmed the efficacy and safety of the antiresus Rh (D) immunoglobulin Rhesogam N for the prevention of Rh isoimmunization.

Publisher

Consilium Medicum

Subject

Obstetrics and Gynecology

Reference17 articles.

1. A Multicenter, Randomized, Open-Label Trial Comparing the Efficacy and Safety of Monoclonal Anti-Rh (D) Immunoglobulin with Polyclonal Anti-Rh (D) Immunoglobulin for the Prevention of Maternal Rh-Isoimmunization

2. Anti-D administration in pregnancy for preventing Rhesus alloimmunisation

3. Прищепенко О.А., Потапова В.Е., Лысенко И.М. Патогенетические основы лечения гемолитической болезни новорожденного. Охрана материнства и детства. 2021;1(37):86-92 [Prischepenko OA, Potapova VE, Lysenko IM. Pathogenetic foundations of treatment of neonatal hemolytic disease. Ohrana materinstva i detstva. 2021;1(37):86-92 (in Russian)].

4. Устьянцева Н.Ю., Путилова Н.В., Чистякова Г.Н. Современные подходы к диагностике и терапии резус-сенсибилизации. Лечение и профилактика. 2020;10(2):89-94 [Ustyanceva NYu, Putilova NV, Chistyakova GN. Modern approaches to the diagnosis and therapy of rh sensitization. The journal of disease treatment and prevention. 2020;10(2):89-94 (in Russian)].

5. Sensitivity of fetalRHDscreening for safe guidance of targeted anti-D immunoglobulin prophylaxis: prospective cohort study of a nationwide programme in the Netherlands

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3