Labor Neuraxial Analgesia and Its Association With Perinatal Outcomes in China in 2015–2016: A Propensity Score–Matched Analysis

Author:

Meng Xi1,Ye Jiangfeng1,Qiao Ping2,Ren Tai1,Luo Qing3,Hu Ling-qun4,Zhang Jun13

Affiliation:

1. Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2. Department of Obstetrics and Gynecology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

3. Department of Research Service, Hainan Women and Children’s Medical Center, Haikou, Hainan, China

4. Department of Obstetric Anesthesiology, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Abstract

BACKGROUND: The use of labor neuraxial analgesia (NA) in China has increased significantly in the past decade, and the current rate of use is unknown. This study aimed to describe the epidemiology of NA based on a large multicenter cross-sectional survey, the China Labor and Delivery Survey (CLDS) (2015–2016), and to evaluate the association between NA and intrapartum caesarean delivery (CD) and maternal and neonatal outcomes. METHODS: The CLDS was a facility-based cross-sectional investigation with a cluster random sampling scheme conducted from 2015 to 2016. A specific weight was assigned to each individual based on the sampling frame. Logistic regression was adopted to analyze the factors associated with the use of NA. A propensity score matching scheme was used to analyze the associations between NA and intrapartum CD and perinatal outcomes. RESULTS: A total of 51,488 vaginal deliveries or intrapartum CD were included in our study, excluding prelabor CDs. The weighted NA rate was 17.3% (95% confidence interval [CI], 16.6–18.0) in this survey population. Nulliparous, previous CD, hypertensive disorders, and labor augmentation were associated with higher use of NA. In the propensity score–matched analysis, NA was associated with reduced risks of intrapartum CD, especially intrapartum CD by maternal request (adjusted odds ratio [aOR], 0.68; 95% CI, 0.60–0.78 and aOR, 0.48; 95% CI, 0.30–0.76, respectively), 3rd or 4th degree perineal laceration (aOR, 0.36; 95% CI, 0.15–0.89), and 5-minute Apgar score ≤3 (aOR, 0.15; 95% CI, 0.03–0.66). CONCLUSIONS: The use of NA may be associated with improved obstetric outcomes, including fewer intrapartum CD, less birth canal trauma, and better neonatal outcomes in China.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Anesthesiology and Pain Medicine

Reference33 articles.

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4. United States state-level variation in the use of neuraxial analgesia during labor for pregnant women.;Butwick;JAMA Netw Open,2018

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