1. Systems Pharmacology Effect Control & Modelling (SPEC-M) Research Group, Anesthesiology Department, Hospital Clinic de Barcelona, Barcelona, Spain
2. Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Technology and Chemistry, University of Navarra, Pamplona, Spain
3. Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain
4. Anesthesiology Department, Hospital Clinic de Barcelona, Barcelona, Spain
5. Institut d’Investigacions Biomèdiques Agusti Pi i Sunyer (IDIBAPS), Barcelona, Spain.