Abstract
Background: Atherogenic index of plasma (AIP) is an index representing the lipid profile of atherogenic dyslipidemia and has been shown to be associated with various atherosclerosis, metabolic diseases, and cardiovascular diseases. However, studies in patients with cerebrovascular disease are still insufficient. In this study, we evaluated the association between AIP and early recurrent ischemic lesions (ERILs) in patients with acute ischemic stroke (AIS).Methods: We included consecutive patients with AIS between 2010 and 2016. ERILs were defined as new diffusion-weighted imaging lesions outside the initial symptomatic lesion area. AIP was calculated using the following formula: AIP=log (triglyceride [mg/dL]/high-density lipoprotein cholesterol [mg/dL]). For subgroup analysis according to stroke mechanism, participants were classif ied into the following four groups: intracranial-large artery atherosclerosis (LAA), extracranial- LAA, cardioembolism, and cryptogenic stroke.Results: A total of 182 patients with AIS were evaluated (median age: 72 years, median initial NIHSS score: 4 [2-13]). In the multivariable analysis, AIP (adjusted odds ratio [aOR], 3.73; 95% confidence interval [CI], 1.01-13.82) was closely associated with ERIL after adjusting confounders. Age and initial NIHSS score were also related to ERIL. Among the four stroke mechanisms, only extracranial-LAA showed significant differences in AIP values between patients with and without ERIL (<i>p</i>=0.028).Conclusion: High AIP was closely related to ERIL in patients with AIS, especially extracranial-LAA stroke. Judging from our results, AIP seems to be involved in the development of new lesions in AIS patients through the mechanisms of atherosclerosis.
Publisher
Korean Society of Neurosonology